Oocyte bụ mmalite ndụ mmadụ, ọ bụ akwa akwa nke na-emecha ghọọ akwa.Agbanyeghị, ogo oocyte na-ebelata ka ụmụ nwanyị na-eto ma ọ bụ n'ihi ihe ndị dị ka oke ibu, na oocytes dị ala bụ isi ihe kpatara ọmụmụ dị ala na ụmụ nwanyị buru ibu.Agbanyeghị, otu esi emeziwanye ogo oocytes na ụmụ nwanyị buru ibu bụ ihe ịma aka nye ndị sayensị.
N'oge na-adịbeghị anya, ọmụmụ ihe akpọrọ nchịkwa nke nicotinamide mononucleotide na-eme ka ogo oocyte nke oke oke buru ibu ka ebipụtara na mmụba Cell.Ọmụmụ ihe ahụ chọpụtara na mgbakwunye nicotinamide adenine dinucleotide (NAD +) precursornicotinamide mononucleosideAcid (NMN) nwere ike imeziwanye mbufụt nke ovarian nke ọma, melite ogo oocyte ma weghachi ịdị arọ nke ụmụ oke na oke ụmụ nwanyị buru ibu.
Ndị nyocha ahụ ahọpụtara ụmụ oke nwanyị dị izu 3 na ụmụ oke nwoke dị izu 11 iji guzobe ụdị oke oke ibu nwere nri nwere oke abụba ma kwado ya site na ndekọ ibu, nnwale glucose ọbara na-ebu ọnụ, na nnwale nnabata glucose ọnụ, ntinye nri. 1 maka izu 2,NMNA na-agbanye ihe mgbakwunye maka ụbọchị iri 10 iji chọpụta okwu nke mkpụrụ ndụ ihe nketa metụtara mmepe ovarian na mkpụrụ ndụ ihe metụtara mbufụt, oke abụba nke anụ ahụ adipose, ụdị oxygen na-emeghachi omume nke oocytes, usoro spindlechromosome, ọrụ mitochondrial, actin dynamics, na mmebi DNA, atụnyere nsonaazụ ndekọ ọnụ ọgụgụ na-egosi:
1. E hiwere ụdị nri oke abụba butere oke oke ibu
Uru FGB nke otu nri nwere oke abụba (HFD) na-adị elu mgbe niile karịa nke otu nri nkịtị (ND), na mgbakwunye, nsonaazụ OGTT gosiri na nri nwere oke abụba (HFD) otu ụmụ oke anaghị anabata glucose.
2. NMN nwere ike imeziwanye mmebi nke metabolic na ụmụ oke HFD
Mgbakwunye naNMNsupplementation belatara oke abụba na ụmụ oke na nri nwere oke abụba (HFD), nsonaazụ ya na-egosi na NMN nwere mmetụta nchebe na metabolism na-adịghị mma na ụmụ oke na nri nwere oke abụba (HFD).
3. NMN na-eme ka ovary dị mma na ụmụ oke HFD
NMN nwere ike imeziwanye ogo ovarian na nri dị oke abụba (HFD) ụmụ oke site n'ịchịkwa okwu nke mkpụrụ ndụ ihe nketa ndị metụtara mmepe ovarian follicle (Bmp4, Lhx8) na mbufụt.
4. NMN na-ebelata ntụpọ nkewa oocyte na mmebi DNA na ụmụ oke HFD
NMN nwere ike ibelata ugboro ugboro nke ntụpọ spindle na chromosomal emezighị emezi nke nri dị oke abụba na-akpata (HFD), belata akara ngosi γH2A.X, na imezi nri abụba dị elu (HFD) - mebiri DNA site na ibelata okwu Bax.
5. NMN nwere ike melite ogo nke oocytes
NMN nwere ike imezi okwu nke SOD1 nke antioxidant na-edozi n'ime nri abụba dị elu (HFD), meziwanye nkesa mitochondria, ma nwee ike melite ogo nke oocytes site n'ịkwado iguzosi ike n'ezi ihe nke cytoskeleton.
6. NMN nwere ike iweghachi nkesa lipid droplet na ụmụ oke HFD
nri nwere oke abụba (HFD) otu oocytes dị elu karịa nke ahụ na nri nkịtị (ND) otu oocytes, yana mgbakwunye NMN nwere ike ibelata fluorescence ike nke ụmụ irighiri mmiri lipid.
7. NMN na-eweghachi ibu ahụ n'ime ụmụ oke HFD
arọ ọmụmụ nke ụmụ nke otu nri nwere oke abụba (HFD) dị obere karịa nke otu nri nkịtị (ND), na mgbakwunye na mgbakwunye NMN weghachiri arọ ọmụmụ nke ụmụ HFD.
N'ime ọmụmụ ihe a, ndị nchọpụta gosipụtara site na nnwale òké na NMN nwere ikike imeziwanye ogo nke oocytes na ụmụ oke oke ibu nke nri nwere oke abụba kpatara, wee kpughee na NMN nwere ike iweghachi ọrụ mitochondrial ma belata mkpokọta ROS na oke ụmụ oke oocytes., DNA mebiri na usoro n'okpuru nkesa lipid droplet.Ya mere, ọmụmụ ihe a ga-enye usoro ọgwụgwọ nwere ike ime ka nsogbu ịmụ nwa na-akpata site na oke ibu na ụmụ nwanyị.
ntụaka:
1.Wang L, Chen Y, Wei J, et al.nchịkwa nke nicotinamide mononucleotide na-eme ka ogo oocyte nke oke oke ibu.Cell Prolif.2022;e13303.doi10.1111cpr.13303
Oge nzipu: Sep-28-2022