Ugwo bụ mmalite ndụ mmadụ, ọ bụ mkpụrụ ndụ àkwá na-etobeghị eto nke na-emecha ghọọ àkwá. Agbanyeghị, ịdị mma nke ugwo ahụ na-ebelata ka ụmụ nwanyị na-aka nká ma ọ bụ n'ihi ihe ndị dị ka oke ibu, ugwo ahụ na-adịghị mma bụ isi ihe na-akpata obere ọmụmụ n'ime ụmụ nwanyị buru ibu. Agbanyeghị, otu esi eme ka ugwo ahụ dịkwuo mma n'ime ụmụ nwanyị buru ibu bụ ihe ịma aka nye ndị ọkà mmụta sayensị.
N'oge na-adịbeghị anya, e bipụtara otu nnyocha akpọrọ Nchịkwa nke nicotinamide mononucleotide na-eme ka oke oke bekee dị mma na mmụba nke mkpụrụ ndụ. Ọmụmụ ihe ahụ chọpụtara na mgbakwunye nke nicotinamide adenine dinucleotide (NAD+) precursornicotinamide mononucleosideAcid (NMN) nwere ike ime ka mbufụt nke akpanwa dịkwuo mma, melite ogo uterine ma weghachi ibu ahụ ụmụ n'ime oke ndị inyom buru ibu.
Ndị nchọpụta ahụ họpụtara òké nwanyị dị izu atọ na òké nwoke dị izu iri na otu iji chọpụta ụdị oke ibu site na nri nwere nnukwu abụba ma kwadoro ya site na ndekọ ibu, ule glucose ọbara na-ebu ọnụ, na ule nnabata glucose ọnụ, ntinye aka nri 1 Maka izu abụọ,NMNA gbara ọgwụ mgbakwunye ruo ụbọchị iri n'usoro iji chọpụta ngosipụta nke mkpụrụ ndụ ihe nketa metụtara mmepe ovarian na mkpụrụ ndụ ihe nketa metụtara mbufụt, nha abụba nke anụ ahụ adipose afọ, ọkwa oocytes nke ụdị oxygen reactive, nhazi spindlechromosome, Ọrụ mitochondrial, actin dynamics, na mmebi DNA, ma e jiri ya tụnyere nsonaazụ ọnụọgụgụ na-egosi:
1. E guzobere ụdị òké nke oke ibu kpatara nri nwere nnukwu abụba nke ọma.
Uru FGB nke otu nri nwere abụba dị elu (HFD) dị elu karịa nke otu nri nkịtị (ND), na mgbakwunye, nsonaazụ OGTT gosiri na oke ndị nwere abụba dị elu (HFD) enweghị ike ịnabata glucose.
2. NMN nwere ike imeziwanye nsogbu metabolic na oke HFD
Mgbakwunye naNMNNtinye ahụ belatara oke abụba n'ime òké n'ime otu nri nwere nnukwu abụba (HFD), nsonaazụ ya na-egosikwa na NMN nwere mmetụta nchebe na metabolism na-adịghị mma na òké n'ime otu nri nwere nnukwu abụba (HFD).
3. NMN na-eme ka ovarian dị mma n'ime òké HFD
NMN nwere ike ime ka ovaries dịkwuo mma n'ime oke nri nwere abụba dị elu (HFD) site n'ịchịkwa ngosipụta nke mkpụrụ ndụ ihe nketa dị mkpa metụtara mmepe nke ovarian follicle (Bmp4, Lhx8) na mbufụt.
4. NMN na-ebelata ntụpọ nkewa nke ude na mmebi DNA na òké HFD
NMN nwere ike ibelata ugboro ole ntụpọ spindle na chromosomal na-adịghị mma nke nri nwere abụba dị elu (HFD) kpatara, belata mgbaàmà γH2A.X, ma belata mmebi DNA nke nri nwere abụba dị elu (HFD) kpatara site na ibelata ngosipụta Bax.
5. NMN nwere ike ime ka mma nke oocytes dịkwuo mma
NMN nwere ike idozi ngosipụta nke SOD1 antioxidant na-adịghị mma na otu nri nwere abụba dị elu (HFD), melite nkesa nke mitochondria, ma nwee ike imeziwanye ogo nke oocytes site na ịnọgide na-enwe iguzosi ike n'ezi ihe nke cytoskeleton.
6. NMN nwere ike iweghachi nkesa lipid droplet na òké HFD
Nri oocytes nwere abụba dị elu (HFD) dị ntakịrị elu karịa nke dị na oocytes otu nri nkịtị (ND), mgbakwunye NMN nwekwara ike ibelata ike fluorescence nke lipid droplets.
7. NMN na-eweghachi ibu ahụ n'ime ụmụ nke òké HFD
Ibu ọmụmụ nke ụmụ sitere na nri nwere nnukwu abụba (HFD) dị obere nke ukwuu karịa nke otu nri nkịtị (ND), mgbakwunye na mgbakwunye NMN weghachiri ibu ọmụmụ nke ụmụ nke otu HFD.
N'ọmụmụ ihe a, ndị nchọpụta gosiri site na nnwale òké na NMN nwere ike ime ka ogo oocytes dịkwuo mma n'ime òké nwanyị buru ibu nke nri nwere abụba dị elu kpatara, ma kpughee na NMN nwere ike iweghachi ọrụ mitochondrial ma belata mkpokọta ROS na oocytes òké nwanyị buru ibu., mmebi DNA na usoro ndị dị n'okpuru nkesa lipid droplet. Ya mere, ọmụmụ ihe a ga-enye usoro ọgwụgwọ nwere ike iji melite nsogbu ọmụmụ nke oke ibu na-akpata na ụmụ nwanyị.
ntụaka:
1.Wang L, Chen Y, Wei J, na ndị ọzọ. Ntinye nicotinamide mononucleotide na-eme ka oke ocyte nke oke ndị buru ibu ka mma. Cell Prolif. 2022; e13303. doi10. 1111cpr.13303
Oge ozi: Sep-28-2022