Clenbuterol, bụ β2-adrenergic agonist (β2-adrenergic agonist), yiri ephedrine (Ephedrine), na-ejikarị ụlọ ọgwụ na-agwọ ọrịa na-adịghị ala ala obstructive pulmonary disease (COPD), A na-ejikwa ya dị ka bronchodilator iji wepụ nnukwu mkparị nke ụkwara ume ọkụ.Na mmalite 1980s, ụlọ ọrụ America Cyanamid chọpụtara na mberede na ọ nwere mmetụta doro anya nke ịkwalite uto, meziwanye ọnụego anụ ahụ na ibelata abụba, ya mere eji ya dị ka clenbuterol na ịzụ anụmanụ.Agbanyeghị, n'ihi nsonaazụ ya, European Community machibidoro iji clenbuterol dị ka ihe mgbakwunye nri kemgbe Jenụwarị 1, 1988. FDA machibidoro ya iwu na 1991. Na 1997, Ministry of Agriculture of the People's Republic of China machibidoro iwu. iji beta-adrenergic hormones na nri na mmepụta anụ ụlọ, na Clenbuterol hydrochloride bụ nke mbụ.
Otú ọ dị, a na-egosi Clenbuterol agbụrụ na nso nso a iji belata ihe ize ndụ nke ọrịa Parkinson.Iji gosi nke (ma ọ bụ abụọ) isomers na-emepụta mmetụta a, dị ọcha Clenbuterol enantiomer kwesịrị ka a mụọ ya iche.
N'ime akụkọ na-adịbeghị anya, otu nnyocha nke Elisabeth Egholm Jacobsen nke Ngalaba Chemistry, Norwegian University of Science and Technology, na mmekorita ya na Dr. Zhu Wei nke Shangke Bio, kwadoro njikọ nke ketoreductase KRED na cofactor nicotinamide adenine dinucleoside phosphate (NADPH). ).(R) -1- (4-Amino-3,5-dichlorophenyl) -2-bromoethan-1-ol, ee> 93%;na (S) -N- (2 bụ nke a na-emepụta site na otu usoro, 6-Dichloro-4- (1-hydroxyethyl) phenyl) acetamide, ee> 98%.Abụọ nke etiti dị n'elu bụ ihe ndị nwere ike ịmalite nke clenbuterol isomers.Ketoreductase ES-KRED-228 ejiri mee ihe n'ọmụmụ ihe a sitere na Shangke Biopharmaceutical (Shanghai) Co., Ltd. Nchọpụta nyocha "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol na Ndị ọzọ -2-Agonists" ka e bipụtara na "Catalysts" na Nọvemba 4, 2018.
Oge nzipu: Ọgọst-26-2022