β-Nicotinamide adenine dinucleotide (anaghị asịd) (NAD)
NAD bụ ihe na-emekarị ka dehydrogenase dị n'ime ihe ndị dị ndụ. Ọ na-esonye na mmeghachi omume redox na ihe ndị dị ndụ, ma na-ebufe ma na-ebufe elektrọn maka ihe ndị dị na mmeghachi omume ahụ. Dehydrogenase na-arụ ọrụ dị mkpa na metabolism mmadụ. Ụfọdụ mmegharị metabolic bụ isi nke ahụ mmadụ, dị ka mmebi protein, mmebi carbohydrate, na mmebi abụba, enweghị ike ime ya n'ụzọ nkịtị na-enweghị dehydrogenase, ndị mmadụ ga-efunahụkwa ihe ịrịba ama dị mkpa. N'ihi na njikọta nke NAD na dehydrogenase nwere ike ịkwalite metabolism, yabụ NAD bụ akụkụ dị mkpa nke ahụ mmadụ. Dịka ojiji ngwaahịa si dị, enwere ike kewaa ya na ọkwa ndị a: ọkwa biotransformation, ọkwa reagent diagnostic, ọkwa nri ahụike, API na ihe eji eme nkwadebe.
| Aha Kemịkal | Nicotinamide adenine dinucleotide (anaghị asịd) |
| Okwu ndị yiri ya | β-Nicotinamide adenine dinucleotide |
| Nọmba CAS | 53-84-9 |
| Ibu Molekụla | 663.43 |
| Usoro Molekụla | C21H27N7O14P2 |
| EINECS gụnyere: | 200-184-4 |
| Ebe agbaze | 140-142 Celsius (mgbawa) |
| okpomọkụ nchekwa. | -20°C |
| mgbaze | H2O: 50 mg/mL |
| ụdị | Ntụ ntụ |
| agba | Ọcha |
| Merck | 14,6344 |
| BRN | 3584133 |
| Ịkwụsi ike: | Ọ dị mma. Ọ na-eme ka ọ dị ọcha. Ọ naghị ekwekọ na ihe ndị na-eme ka oxidation sie ike. |
| InChiKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Ihe Nnwale | Nkọwapụta |
| Ọdịdị | Ntụ ntụ kristal ọcha ruo ọcha |
| Nyocha UV spectral εna 260 nm na pH 7.5 | (18±1.0) ×10³ L/mol/cm |
| Mmiri na-agbaze | 25mg/mL 25mg/mL n'ime mmiri |
| Ọdịnaya (site na nyocha enzymatic na ADH na pH 10, site na iji spectrophotometer, abs.340nm, dabere na mmiri anaghị agbaze) | ≥98.0% |
| Nnwale (site na HPLC, dabere na mmiri na-anaghị agbaze) | 98.0~102.0% |
| Ịdị ọcha (site na HPLC, %mpaghara) | ≥99.0% |
| Mmiri dị n'ime ya (site na KF) | ≤3% |
Ngwugwu:Karama, akpa foil Aluminom, 25kg/Kaadọn Drum, ma ọ bụ dịka ihe onye ahịa chọrọ si dị.
Ọnọdụ Nchekwa:Debe ya n'ime ebe gbara ọchịchịrị, debe ya na okpomọkụ nke 2-8 ℃ maka nchekwa ogologo oge.
Ọkwa mgbanwe bio: Enwere ike iji ya maka njikọta biocatalytic nke ndị na-emepụta ọgwụ na API, ọkachasị na enzymes catalytic, dịka ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH)), glucose dehydrogenase (GDH), wdg, nke nwere ike ijikọ aka gbanwee ọtụtụ amino acid intermediates na ọgwụ ndị ọzọ metụtara ya. Ugbu a, ọtụtụ ụlọ ọrụ ọgwụ n'ime obodo amalitela itinye nnọchi enzyme bayoloji, ọchịchọ ahịa maka NAD+ na-eto ngwa ngwa.
Ọkwa ihe nchọpụta ọrịa: Ejikọtara ya na ọtụtụ enzymes nchọpụta ọrịa, dị ka ihe e ji eme ihe na ngwa nchọpụta ọrịa.
Nri Ahụike: NAD bụ coenzyme nke dehydrogenase. Ọ na-arụ ọrụ a na-apụghị ịgbanwe agbanwe na glycolysis, gluconeogenesis, usoro tricarboxylic acid, na usoro iku ume, na-arụ ọrụ dị mkpa na mmepụta ike, ma na-enyere aka na mmepụta nke L-dopa, nke na-aghọ dopamine Neurotransmitters. Karịsịa n'afọ ndị na-adịbeghị anya, achọpụtala na ọ bụ "engine" na "mmanụ ọkụ" na usoro ndozi mmebi sel. Dịka nyocha si kwuo, mgbakwunye nke coenzymes (gụnyere NMN, NR, NAD, NADH) in vitro nwere ike ime ka ikike antioxidant nke sel anụ ahụ dịkwuo mma, gbochie akara apoptosis, weghachi ọrụ sel nkịtị, gbochie ọrịa ma ọ bụ igbochi ọganihu ọrịa.
Tinyere nke ahụ, coenzymes nwere ike ime ka ikike nzaghachi ahụ ji alụso ọrịa ọgụ dịkwuo mma site n'ịrụ ọrụ na ịkwalite ntozu nke mkpụrụ ndụ ahụ ji alụso ọrịa ọgụ, na-emepụta ihe ndị na-egbochi mbufụt na igbochi mkpụrụ ndụ T na-achịkwa. Nicotinamide dinucleotide oxidation state (NAD+) bụ coenzyme dị na mkpụrụ ndụ niile dị ndụ. Ọ na-arụ ọrụ dị mkpa na ọtụtụ narị usoro metabolic na mkpụrụ ndụ, na-esonye na ọtụtụ puku mmeghachi omume physiological, ọ bụkwa onye kachasị mkpa na usoro njem elektrọn. Onye nyere hydrogen; n'otu oge ahụ, coenzyme I na-arụ ọrụ dị ka naanị ihe mejupụtara enzymes metụtara ya n'ahụ, na-enyere aka ịnọgide na-arụ ọrụ nke enzymes.
Nicotinamide mononucleotide (NMN) bụ ihe mejupụtara nicotinamide adenine dinucleotide oxidation state (NAD+), nke na-etinye aka na mmepụta nke NAD in vivo. Na 2013, Prọfesọ David Sinclair nke Harvard Medical School chọpụtara na ka afọ na-aga, ọkwa cofactor coenzyme I (NAD+) nke protein ogologo oge n'ahụ na-aga n'ihu na-ebelata, nke na-eduga na mbelata nke ọrụ mitochondrial nke "dynamo" nke sel ahụ, na-akpali ịka nká, na ihe dị iche iche dị n'ahụ. N'ihi ya, a na-emepụta nsogbu nke ụdị ọrụ a. Dịka usoro ọmụmụ ya si kwuo, ọdịnaya nke NAD+ n'ahụ mmadụ na-ebelata ka afọ na-aga, na-ebute ịka nká ngwa ngwa site na afọ 30, yana wrinkles, izu ike akwara, mkpokọta abụba, na ọrịa dịka ọrịa obi, ọbara mgbali elu, strok, ọrịa shuga na ọrịa Alzheimer na-abawanye ihe egwu. Isi ihe na-eme ka ogologo ndụ dị ogologo bụ ịbawanye ọkwa nke coenzyme I (NAD+) n'ahụ, ịbawanye ọnụego nke metabolism sel, ma kpalite ike ntorobịa nwere ike ịdị.
Ngwa API na nkwadebe: A na-eji NAD+ agba ọgwụ maka ọgwụgwọ/njikwa ọgwụ riri ahụ, gụnyere ọgwụgwọ NAD IV nke etinyere na United States, Europe, Russia, South Africa, Mexico, South America, Southeast Asia na mba ndị ọzọ. Ngwaahịa ndị a kwadebere n'onwe ha maka ọgwụ, dị ka ụlọ ọgwụ ndị America, nwere ike ịzụta ihe eji emepụta ọgwụ maka onwe ha, dịka nkwadebe ụlọ ọgwụ ndị China, ọ na-achịkwa ịdị mma nke ihe eji emepụta ọgwụ n'onwe ya, ma na-akwadebe nkwadebe ka ọ bụrụ ọgwụ.
