β-Nicotinamide adenine dinucleotide (free acid) (NAD)
NAD bụ coenzyme a na-ahụkarị nke dehydrogenase n'ime ihe ndị dị ndụ.Ọ na-ekere òkè na mmeghachi omume redox na ihe ndị dị ndụ, na-ebufe ma na-ebufe electrons maka ihe ndị dị na mmeghachi omume.Dehydrogenase na-arụ ọrụ dị mkpa na metabolism nke mmadụ.Ụfọdụ mmegharị ahụ nke metabolic bụ isi nke ahụ mmadụ, dị ka ire ere protein, ire carbohydrate, na ire abụba, enweghị ike ịme ya nke ọma na-enweghị dehydrogenase, ndị mmadụ ga-atụfu akara ngosi dị mkpa.Na n'ihi na ngwakọta nke NAD na dehydrogenase nwere ike ịkwalite metabolism, yabụ NAD bụ akụkụ dị mkpa nke ahụ mmadụ.Dị ka ojiji ngwaahịa si dị, enwere ike kewaa ya na ọkwa ndị a: ọkwa biotransformation, ọkwa reagent diagnostic, ọkwa nri ahụike, API na akụrụngwa nkwadebe.
| Aha Chemical | Nicotinamide adenine dinucleotide (free acid) |
| Ụdị okwu | β-Nicotinamide adenine dinucleotide |
| Nọmba CAS | 53-84-9 |
| Ibu molekụla | 663.43 |
| Usoro ihe omimi | C21H27N7O14P2 |
| EINECS gụnyere: | 200-184-4 |
| Ebe mgbaze | 140-142C (decomp) |
| nchekwa okpomọkụ. | -20°C |
| solubility | H2O: 50 mg/mL |
| ụdị | Ntụ ntụ |
| agba | Ọcha |
| Merck | 14,6344 |
| BRN | 3584133 |
| Nkwụsi ike: | Kwụsie ike.Hygroscopic.Ekwekọrịtaghị na ndị ọrụ oxidizing siri ike. |
| InChiKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Nwale ihe | Nkọwapụta |
| Ọdịdị | Uzuzu crystalline na-acha ọcha ruo na-acha ọcha |
| UV spectral nyocha ε260nm na pH 7.5 | (18± 1.0) × 10³ L/mol/cm |
| Solubility | 25mg/mL 25mg/mL n'ime mmiri |
| Ọdịnaya (site na nyocha nke enzymatic na ADH na pH 10, na-eji spectrophotometer, abs.340nm, na ndabere enweghị mmiri) | ≥98.0% |
| Nnwale (nke HPLC, na ndabere anhydrous) | 98.0 ~ 102.0% |
| Ịdị ọcha (nke HPLC,% mpaghara) | ≥99.0% |
| Ọdịnaya mmiri (nke KF) | ≤3% |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe nke ọma na ọchịchịrị, maka nchekwa ogologo oge, debe ya na 2 ~ 8 ℃.
Ọkwa biotransformation: Enwere ike iji ya maka njikọ biocatalytic nke intermediates ọgwụ na API, tumadi na enzymes catalytic, dị ka ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH) ), glucose dehydrogenase (FDH) GDH), wdg, nke nwere ike imekọ ihe ọnụ iji gbanwee etiti amino acid dị iche iche na ọgwụ ndị ọzọ metụtara ya.Ka ọ dị ugbu a, ọtụtụ ụlọ ọrụ na-emepụta ọgwụ ụlọ amalitela itinye ngbanwe nke enzyme ndu, na ahịa ahịa maka NAD + na-eto ngwa ngwa.
Ọkwa reagent nchọpụta: Ejikọtara ya na ọtụtụ enzymes nyocha, dị ka akụrụngwa nke ngwa nyocha.
Ọkwa nri ahụike: NAD bụ coenzyme nke dehydrogenase.Ọ na-arụ ọrụ na-enweghị atụ na glycolysis, gluconeogenesis, usoro tricarboxylic acid, na agbụ iku ume, na-arụ ọrụ dị mkpa na mmepụta ume, ma na-enyere aka na mmepụta nke L-dopa, nke na-aghọ dopamine Neurotransmitters.Karịsịa n'ime afọ ndị na-adịbeghị anya, a chọpụtala na ọ bụ "engine" na "mmanụ ọkụ" na-arụ ọrụ nrụzi mmebi cell.Dị ka nchọpụta si kwuo, mgbakwunye nke coenzymes (gụnyere NMN, NR, NAD, NADH) in vitro nwere ike ịkwalite ikike antioxidant nke mkpụrụ ndụ anụ ahụ, gbochie apoptosis mgbaàmà, weghachite ọrụ sel nkịtị, gbochie ọrịa ma ọ bụ gbochie ọganihu ọrịa.
Tụkwasị na nke ahụ, coenzymes nwere ike ime ka ikike nke nzaghachi na-alụso ọrịa ọgụ dịkwuo elu site n'ịgbalite na ịkwalite maturation nke mkpụrụ ndụ na-alụso ọrịa ọgụ, na-emepụta ihe ndị na-egbochi mkpali ma na-egbochi sel T na-achịkwa.Nicotinamide dinucleotide oxidation state (NAD +) bụ coenzyme dị na sel niile dị ndụ.Ọ na-arụ ọrụ dị mkpa na narị otu narị usoro metabolic na sel, na-ekere òkè na puku kwuru puku mmeghachi omume anụ ahụ, ma bụrụkwa onye kachasị mkpa na agbụ ụgbọ njem elektrọn.Onye na-enye hydrogen;N'otu oge ahụ, coenzyme m na-arụ ọrụ dị ka naanị mkpụrụ nke enzymes metụtara na ahụ, na-enyere aka ịnọgide na-arụ ọrụ nke enzymes.
Nicotinamide mononucleotide (NMN) bụ precursor compound nke nicotinamide adenine dinucleotide oxidation steeti (NAD +), nke na-etinye aka na njikọ nke NAD na vivo.Na 2013, Prọfesọ David Sinclair nke Harvard Medical School chọpụtara na ka ọ na-etolite, ọkwa cofactor coenzyme I (NAD +) nke protein ogologo ndụ n'ime ahụ na-aga n'ihu na-agbada, nke na-eduga na mbelata ọrụ mitochondrial nke "dynamo" cell, na-akpata ịka nká. , na ihe dị iche iche dị na ahụ.A na-esi otú a mepụta arụrụ arụ nke ụdị ọrụ a.Dị ka usoro ọmụmụ ya si kwuo, ọdịnaya NAD + na ahụ mmadụ na-ebelata ka afọ, na-ebute ịka nká ngwa ngwa site na afọ 30, na wrinkles, ahụ ike anụ ahụ, nchịkọta abụba, na ọrịa ndị dị ka ọrịa obi, ọbara mgbali elu, ọrịa strok. , ọrịa shuga na ọrịa Alzheimer mụbara ihe ize ndụ.Isi ihe na-eme ka ndụ dị ogologo bụ ịbawanye ọkwa nke coenzyme I (NAD+) n'ime ahụ, mụbaa ọnụ ọgụgụ nke metabolism cell, ma kpalie ike ntorobịa nwere ike.
API na nkwadebe akụrụngwa: A na-eji NAD + na injections maka ọgwụgwọ / njikwa ọgwụ riri ahụ, gụnyere NAD IV ọgwụgwọ intravenous etinyere na United States, Europe, Russia, South Africa, Mexico, South America, Southeast Asia na mba ndị ọzọ.Ngwa ahịa ụlọ ahịa akwadoro onwe ya, dị ka ụlọ ahịa ọgwụ America, nwere ike zụta akụrụngwa maka inye onwe ya, dị ka nkwadebe ụlọ ọgwụ China, ọ na-achịkwa ogo akụrụngwa n'onwe ya, ma na-akwadebe nkwadebe n'ime ọgwụ.
