N'afọ ndị na-adịbeghị anya, ka ụdị ndụ na-adịghị mma na-abawanye na nrụgide mmekọrịta mmadụ na ibe ya nke ụmụ nwanyị, ọnụọgụgụ nke ọrịa polycystic ovary syndrome (PCOS) apụtala ìhè nke ukwuu. Ọmụmụ ihe ndị mba ọzọ egosila na ọnụọgụgụ nke ọrịa polycystic ovary syndrome (PCOS) n'ime ụmụ nwanyị dị afọ ịmụ nwa dị elu ruo 6% -15%, ebe na China, nkezi ya dị elu ruo 6% -10%.
Ọrịa ovary polycystic bụ ọrịa nke na-emekarị n'ime ụmụ nwanyị dị afọ ịmụ nwa n'ihi nsogbu endocrine. Ọ na-apụtakarị na glucose na metabolism lipid na-adịghị mma yana nsogbu ịmụ nwa. Ihe ndị a na-achọpụta n'ụlọ ọgwụ bụ nsogbu ọkwa homonụ (oke androgen), nsogbu ovulation na mgbanwe polycystic nke ovary, ọtụtụ ụmụ nwanyị nwere PC COS nwere njirimara metabolic na-adịghị mma, dị ka iguzogide insulin, oke ibu, na steatosis imeju.
Ugbu a, enwere obere ọgwụ maka ọgwụgwọ PCOS. Ụzọ a na-ejikarị eme ihe bụ ime ka PCOS ka mma site n'itinye aka na igbochi oke androgen site na iji ọgwụ anti-androgen. Agbanyeghị, enwere ihe akaebe na ọgwụ anti-androgen nwere nnukwu nsị imeju, yabụ ojiji ha pere mpe. Ya mere, ọ dị oke mkpa ịchọ ihe sitere n'okike na-enweghị mmetụta ọjọọ iji dochie ọgwụ ndị dị ugbu a.
Nnyocha e mere n'oge na-adịbeghị anya nke Mahadum New South Wales dị na Australia chọpụtara na ọrịa polycystic ovary syndrome metụtara enweghị NAD+, e bipụtakwara nsonaazụ nyocha ahụ na akwụkwọ akụkọ sayensị bụ "Molecular Metabolism".
Ndị otu nnyocha ahụ buru ụzọ tinye dihydrotestosterone (DHT) n'ime oke ụmụ nwanyị tupu na mgbe ha tolitere iji guzobe ụdị òké PC COS, wee mechaa mgbe izu asatọ nke ọgwụgwọ NMN gasịrị, insulin na-ebu ọnụ na nchọpụta iguzogide insulin HOMA, ule nnabata glucose, na abụba Mgbe ule dịka histomorphometry gasịrị, nsonaazụ ọnụọgụgụ na-egosi:
1. N MN na-eweghachi ọkwa N AD + n'ime akwara nke òké P COS
chọpụtara na ọkwa NAD+ dị n'akwara nke òké PCOS belatara nke ukwuu, e mekwara ka ọkwa NAD dị n'akwara nke òké PCOS dịghachi site n'inye nri NMN.
2. NMN na-eme ka iguzogide insulin na oke ibu dịkwuo mma na òké PCOS
Ọkwa insulin nke DHT kpatara karịrị okpukpu abụọ n'ime òké PCOS na-ebu ọnụ, ikekwe na-egosipụta iguzogide insulin. Site n'inye NMN nri, achọpụtara na ọkwa insulin na-ebu ọnụ eweghachiri na ọkwa dị nso na nke òké nkịtị. Na mgbakwunye, ibu ahụ nke òké PCOS mụbara site na 20%, oke abụba mụbara nke ukwuu.
3. NMN na-eweghachi ihe ndị na-adịghị mma na-etinye n'ime oke PCOS
Otu n'ime ihe ndị na-egosi ọrịa ovary polycystic bụ ọnụnọ lipid n'ime imeju na mmụba nke imeju abụba. Mgbe e jiri NMN mee ihe, ihe ndị na-adịghị mma n'ime oke PCOS fọrọ nke nta ka ọ gwụchaa, triglycerides dị n'ime imeju wee laghachi n'ọkwa òké nkịtị.
Nkwubi okwu a gosiri na ọkwa NAD+ dị n'ime akwara PCOS belatara nke ukwuu, a gwọkwara ọnọdụ PCOS site na ịgbakwunye NMN, nke bụ ihe na-ebute NAD+, nke nwere ike ịbụ usoro ọgwụgwọ maka ọgwụgwọ PCOS.
ntụaka:
[1]. Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Mbelata akwara NAD+ na hyperandrogenism Ụdị òké PCOS: Ọrụ nwere ike ime na nsogbu metabolic. Mol Metab. Sep 9 2022;65:101583. doi: 10.1016/j.molmet.2022.101583. Epub tupu mbipụta. PMID: 36096453.
Oge ozi: Nọvemba-17-2022