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NMN na-ebelata fibrosis intestinal nke radieshon na-ebute site n'ịgbanwe microbiota gut

Fibrosis nke eriri afọ na-akpata radieshon bụ ihe mgbagwoju anya nke ndị na-adịte aka ogologo oge mgbe ọgwụgwọ redio nke afọ na pelvic gasịrị.Ka ọ dị ugbu a, ọ nweghị usoro ụlọ ọgwụ dị maka ọgwụgwọ fibrosis nke eriri afọ na-akpata radieshon.Nnyocha e mere egosiwo na nicotinamide mononucleotide (NMN) nwere ikike ịhazi osisi intestinal.Osisi intestinal bụ microorganism nkịtị na eriri afọ mmadụ, nke nwere ike ịmepụta ụdị nri dị iche iche dị mkpa maka uto na mmepe mmadụ.Ozugbo osisi intestinal enweghị nguzozi, ọ ga-ebute ọrịa dị iche iche.
Na nso nso a, China Academy of Medical Sciences na Peking Union Medical College bipụtara nsonaazụ nyocha na akwụkwọ akụkọ International Journal of Radiation Biology, nke gosipụtara na NMN nwere ike belata fibrosis intestinal nke radieshon kpatara site na ịhazi ahịhịa intestinal.
Na mbụ, ndị otu nyocha kewara ụmụ oke ndị ahụ n'ime otu njikwa, NMN Group, IR group na NMNIR otu, ma nye 15 Gy abdominal irradiation na ndị otu IR na NMNIR.Ka ọ dị ugbu a, e nyere mgbakwunye NMN na otu NMN na otu NMNIR na dose kwa ụbọchị nke 300mg/kg.Mgbe ị were ya ruo oge ụfọdụ, site na ịchọpụta nsị òké, microflora intestinal na eriri anụ ahụ, nsonaazụ atụnyere gosiri na:

1. NMN nwere ike ịrụzi ihe mejupụtara na ọrụ nke intestinal flora nke radieshon na-akpaghasị.
Site n'ịtụle nchọpụta nke intestinal flora n'etiti IR Group na NMNIR otu, a chọpụtara na IR ìgwè ụmụ oke na-amụba ụba nke na-emerụ intestinal flora, dị ka Lactobacillus du, Bacillus faecalis, wdg N'ụzọ dị ịtụnanya, NMNIR otu ụmụ oke gbanwere iche iche nke eriri afọ flora. ma mụbaa ụbara ahịhịa nke eriri afọ bara uru, dị ka nje bacteria AKK, site n'ịgbakwụnye NMN.Nnwale na-egosi na NMN nwere ike ịrụzi ihe mejupụtara na ọrụ nke osisi intestinal nke na-enweghị nguzozi n'ihi radieshon.

modulating gut microbiota12. NMN na-ebelata fibrosis intestinal nke radieshon kpatara
Ọkwa aSMA (Fibrosis Marker) n'ime ụmụ oke ekpughere na radieshon mụbara nke ukwuu.Mgbe mgbakwunye NMN gasịrị, ọ bụghị naanị ọkwa nke akara aSMA belatara nke ukwuu, kamakwa ihe mkpali TGF-b nke kwalitere fibrosis intestinal belatara nke ukwuu, na-egosi na mgbakwunye NMN nwere ike ibelata fibrosis intestinal nke radieshon kpatara.

modulating gut microbiota2

(Nyocha 1. NMN ọgwụgwọ na-ebelata fibrosis intestinal nke radieshon kpatara)

N'okpuru ndabere nke mgbasawanye nke ngwaahịa eletrọnịkị, radieshon na-enwe mmetụta na-arịwanye elu na ọrụ na ndụ ndị mmadụ, karịsịa na osisi eriri afọ ruo ogologo oge.NMN nwere mmetụta nchebe siri ike na ahụike eriri afọ.Ọ bụghị nanị na a ghọtara mmetụta a site na otu ihe ma ọ bụ ụzọ ụfọdụ, kamakwa site n'ịhazi nhazi nkesa nke osisi iji kwalite nkwụsi ike nke ọrụ intestinal site n'akụkụ dị iche iche na ntụziaka, nke na-enyekwa nkọwa dị mkpa maka uru dị iche iche nke NMN.

Ntụaka:
Xiaotong Zhao, Kaihua Ji.


Oge nzipu: Dec-08-2022