Macrophage activation bụ usoro ọrịa na-ebute ọrịa na-adịghị ala ala n'ime ahụ, mana ịgbalite macrophage na-adịgide adịgide nwere ike ibute mbufụt na-adịghị ala ala na ọrịa ndị dị ka nguzogide insulin na ọrịa siri ike dị ka atherosclerosis.PGE 2, nke na-eme ka mmeghachi omume na-egbuke egbuke, sitere na arachidonic acid site na cyclooxygenases (COX-1 na COX-2).COX-1 na COX-2 bụ isi ebumnuche nke mgbochi mkpali na enwere ike igbochi ya site na ọgwụ ndị na-abụghị steroidal anti-inflammatory (NSAIDs).
iji NSAIDs eme ihe nwere ike ịkpata ọtụtụ mmeghachi omume ọjọọ, dị ka ọbara ọgbụgba nke eriri afọ.Ya mere, ọ dị mkpa karịsịa ịchọta ihe sitere n'okike dị nchebe iji gwọọ mbufụt .
Na nso nso a, otu nnyocha otu si Tsinghua University mesoo òké macrophages na NMN, na-egosi site na nnwale na NMN nwere ike ibelata mkpokọta nke mbufụt-metụtara protein na metabolic byproducts, na-egbochi mkpali nzaghachi nke macrophages.Ihu ihu na Molecular Biosciences .
Mbufụt na-agbanwe ọkwa nke metabolic byproducts na macrophages
Nke mbụ, ndị otu nyocha ahụ na-arụ ọrụ macrophages iji mepụta mbufụt site na lipopolysaccharide (LPS), wee nyochaa ọdịnaya nke ngwaahịa ndị dị na gburugburu macrophages n'oge mbufụt.A na-abawanye ọkwa nke metabolites 99 yana 105 metabolites belatara n'etiti mkpụrụ ndụ 458 achọpụtara tupu na mgbe mkpali mkpali, na ọkwa NAD + na-eso mbufụt belatara.
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NMN na-abawanye ọkwa NAD ma belata mbufụt macrophage
Ndị otu nyocha ahụ mesoo macrophages na LPS, nke na-ebute ọnọdụ mkpasu iwe, IL-6 na IL-1β, cytokines pro-inflammatory nke na-eme dị ka akara nke mbufụt.Mgbe ọgwụgwọ NMN gasịrị nke mbufụt macrophage nke LPS kpatara, a chọpụtara na ọkwa NAD intracellular na-abawanye yana okwu mRNA nke IL-6 na IL-1β belatara.Nnwale gosipụtara na NMN mụbara ọkwa nke NAD ma belata mbufụt macrophage nke LPS kpatara.
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NMN na-ebelata ọkwa protein metụtara mbufụt
NMN ọgwụgwọ, a chọpụtara na protein ndị metụtara mbufụt dị ka RELL1 , PTGS2, FGA, FGB na igkv12-44 na-ebelata na mkpụrụ ndụ , nke gosiri na NMN belatara okwu nke mbufụt metụtara protein.
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NMN na-ebelata nkwupụta nke protein ebumnuche NSAIDS
Nnwale ikpeazụ ahụ chọpụtara na NMN belatara ọkwa PGE2 na sel RAW264.7 na-arụ ọrụ LPS site na ibelata ọkwa nkwupụta nke COX-2, si otú ahụ belata okwu COX2 na igbochi mbufụt nke LPS.
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nkwubi okwu , supplementation nke NMN nwere ike na-agwọ ọrịa na-adịghị ala ala nke ọma na ụmụ oke, na ọgwụgwọ nke mbufụt na ụmụ mmadụ ka kwesịrị nkwenye site na ule ụlọ ọgwụ dị mkpa.Ikekwe NMN ga-aghọ onye nnọchi NSAIDS n'ọdịnihu dị nso.
ntụaka:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide na-eme ka LPS na-akpata Mgbu na Oxidative Stress site na Mbelata COX-2 Okwu na Macrophages.N'ihu Mol Biosci.2021 Julaị 6.
Oge nzipu: Nov-26-2022