Nnyocha Express | Ọmụmụ ihe Mahadum Tsinghua gosiri na NMN nwere ike ịgwọ mbufụt

Mmelite macrophage bụ usoro na-akpata ọrịa na-ebute mbufụt na-adịghị ala ala n'ahụ, mana ime ka macrophage na-aga n'ihu nwere ike ibute mbufụt na-adịghị ala ala na ọrịa dịka iguzogide insulin na ọrịa siri ike dịka atherosclerosis. PGE 2, nke na-eme ka mmeghachi omume mkpali pụta, sitere na arachidonic acid site na cyclooxygenases (COX-1 na COX-2). COX-1 na COX-2 bụ isi ihe na-ebute mgbochi mbufụt ma enwere ike igbochi ya site na ọgwụ mgbochi mkpali na-abụghị steroidal (NSAIDs).

Iji NSAIDs eme ihe nwere ike ibute ọtụtụ mmeghachi omume ọjọọ, dịka ọbara ọgbụgba afọ. Ya mere, ọ dị mkpa karịsịa ịchọta ihe sitere n'okike dị nchebe iji gwọọ mbufụt.

N'oge na-adịbeghị anya, otu ndị nyocha sitere na Mahadum Tsinghua jiri NMN gwọọ macrophages òké, ma gosipụta site na nnwale na NMN nwere ike ibelata mkpokọta protein ndị metụtara mbufụt na ngwaahịa metabolic, ma gbochie mmeghachi omume mkpali nke macrophages.

Mbufụt na-agbanwe ọkwa nke ihe ndị na-emepụta metabolic na macrophages
Nke mbụ, ndị otu nyocha ahụ mere ka macrophages mepụta mbufụt site na lipopolysaccharide (LPS), wee nyochaa ọdịnaya nke ihe ndị sitere na macrophages n'oge mbufụt. Ọkwa nke metabolites 99 mụbara ma belata metabolites 105 n'ime molekul 458 achọpụtara tupu na mgbe mkpali mbufụt gasịrị, ọkwa NAD+ nke na-eso mbufụt belatakwara.

(NỌMBA 1)

NMN na-eme ka ọkwa NAD dịkwuo elu ma na-ebelata mbufụt macrophage
Ndị otu nnyocha ahụ jiri LPS gwọọ macrophages, nke na-akpata ọnọdụ mkpali, IL-6 na IL-1β, cytokines pro-inflammatory nke na-arụ ọrụ dị ka ihe nrịbama nke mbufụt. Mgbe ọgwụgwọ NMN nke mbufụt macrophage nke LPS kpatara gasịrị, achọpụtara na ọkwa NAD dị n'ime ahụ mụbara ma gosipụta mRNA nke IL-6 na IL-1β belatara. Nnwale gosiri na NMN mụbara ọkwa NAD ma belata mbufụt macrophage nke LPS kpatara.

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NMN na-ebelata ọkwa protein metụtara mbufụt
Mgbe a na-agwọ NMN, achọpụtara na protein ndị metụtara mbufụt dịka RELL1, PTGS2, FGA, FGB na igkv12-44 ebelatala na mkpụrụ ndụ, nke gosiri na NMN belatara ngosipụta nke protein ndị metụtara mbufụt.

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NMN na-ebelata ngosipụta nke protein ndị NSAIDS lekwasịrị anya
Nnwale ikpeazụ ahụ chọpụtara na NMN belatara ọkwa PGE2 na mkpụrụ ndụ RAW264.7 nke LPS na-arụ ọrụ site na ibelata ọkwa ngosipụta nke COX-2, si otú a belata ngosipụta nke COX2 ma gbochie mbufụt nke LPS kpatara.

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Nkwubi okwu a pụtara na mgbakwunye nke NMN nwere ike ịgwọ mbufụt na-adịghị ala ala n'ime òké nke ọma, a ka kwesịrị ịchọpụta ọgwụgwọ mbufụt n'ime ụmụ mmadụ site na nnwale ụlọ ọgwụ dị mkpa. Ikekwe NMN ga-abụ ihe nnọchi anya NSAIDS n'ọdịnihu dị nso.

ntụaka:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide na-eme ka LPS na-akpata Mgbu na Oxidative Stress site na Mbelata COX-2 Okwu na Macrophages. N'ihu Mol Biosci. 2021 Julaị 6.