Hypopigmentation bụ ọrịa akpụkpọ, nke na-apụtakarị site na mbelata melanin.Mgbaàmà ndị a na-ahụkarị gụnyere vitiligo, albinism na hypopigmentation mgbe mbufụt akpụkpọ.Ka ọ dị ugbu a, ọgwụgwọ bụ isi maka hypopigmentation bụ ọgwụ ọnụ, mana ọgwụ ọnụ ga-eme ka atrophy akpụkpọ anụ, ahụ erughị ala eriri afọ na mmetụta ọjọọ ndị ọzọ.Ya mere, ọ dị mkpa ịmepụta ihe okike na-enweghị mmetụta na-adịghị mma iji na-emeso hypopigmentation.
N'oge na-adịbeghị anya, Scientific Reports bipụtara otu isiokwu isiokwu ya bụ "Nnyocha nhazi na-ekpughe ikike nke spermidine maka ọgwụgwọ hypopigmentation | site na nkwụsi ike nke protein ndị metụtara melanogenesis".Nsonaazụ na-egosi na enwere ike ịgwọ spermidine site na ịkwado protein ndị metụtara melanogenesis.hypopigmentation.
一, Ọgwụgwọ Spermidine na-abawanye mmepụta nke melanin
Iji nyochaa mmetụta spermidine na mmepụta nke melanin, ndị otu nyocha ahụ na-emeso melanin n'ime sel MNT-1 na ọkwa dị iche iche nke spermidine.Site na nyocha ọnụọgụgụ, a chọpụtara na ọgwụgwọ spermidine mụbara mmepụta melanin.
Spermidine nwere ike ịhazi usoro mmebi protein metụtara melanogenesis
Iji gosi na spermidine nwere ike ịchịkwa mkpụrụ ndụ ihe nketa na-etinye aka na mmebi protein, ndị otu nyocha ahụ chọpụtara 181 genes ala na-achịkwa na 82 genes elu na-achịkwa site n'ịchọpụta mkpụrụ ndụ spermidine na-agwọ ọrịa, ewezuga mkpụrụ ndụ ihe nketa metụtara melanogenesis.Iji gosi n'ihu, ndị otu nyocha nyochara mmetụta spermidine na ọkwa ngosipụta nke ezinụlọ tyrosinase TYR, TRP-1 na TRP-2, bụ mkpụrụ ndụ ihe nketa na-achịkwa mmepụta nke melanin.Ọkwa okwu mRNA kwadoro na spermidine agbanweghị okwu mkpụrụ ndụ ihe nketa metụtara melanogenesis.Otú ọ dị, ọrụ nke ọtụtụ mkpụrụ ndụ ihe nketa na-agbanwe site na spermidine na metụtara mmebi protein.Ọtụtụ mkpụrụ ndụ ihe nketa gbanwere na-emetụta ebe niile, nke bụ usoro mmebi protein metụtara melanogenesis.
Spermidine na-achịkwa nkwụsi ike nke protein ma na-akwalite mmepụta melanin.
A na-ahazi mmepụta nke melanin site na nguzozi nke njikọ na mmebi nke protein ndị metụtara melanin.Spermidine na-emeso mkpụrụ ndụ ihe nketa TYR, TRP-1 na TRP-2.Site na omume nke mkpụrụ ndụ ihe nketa SLC3A2, SLC7A1, SLC18B1 na SLC22A18, ọ nwere ike ịbawanye ọkwa nke polyamines na sel, si otú ahụ na-abawanye nkwụsi ike nke protein ndị metụtara mmepụta melanin iji kwalite mmepụta melanin na vivo.
N'ikpeazụ, ọmụmụ ihe a na-egosi na spermidine na-emepụta ihe nwere ike ịrụ ọrụ na ọgwụgwọ nke hypopigmentation, ma nwee ụfọdụ uru ngwa n'ọhịa nke ịchọ mma na ngwaahịa ahụike n'ọdịnihu.
Ntụaka:
[1].Brito, S., Heo, H., Cha, B. et al.Nnyocha nhazi usoro na-ekpughe ikike nke spermidine maka ọgwụgwọ hypopigmentation site na nkwụsi ike nke protein ndị metụtara melanogenesis.Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Oge nzipu: Sep-28-2022