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Nucloside phosphoryalse (NP)
Banyere phosphoryalse nucleoside
E nwere ụdị ngwaahịa NP enzyme atọ (Nọmba dịka ES-NP-101~ ES-NP-103) nke SyncoZymes mepụtara. ES-NP-101 bụ purine nucleoside phosphorylase, ES-NP-102 na ES-NP-103 bụ pyrimidine nucleoside phosphorylase. Nucleosidephosphorylase nwere ike ịgbari nucleosides ka ọ bụrụ ntọala na pentose phosphate. Enwere ike kewaa Nucleoside phosphorylase ka ọ bụrụ purine nucleoside phosphorylase na pyrimidine nucleoside phosphorylase dịka nhọrọ nke nucleoside bases si dị. Purine nucleoside phosphorylase nwere ike ịgbari adenosine ka ọ bụrụ adenine, inosine ka ọ bụrụ hypoxanthine, guanosine ka ọ bụrụ guanine, ma mepụta ribose phosphate n'otu oge. Pyrimidine nucleoside phosphorylase nwere ike ịgbari uridine ka ọ bụrụ uracil ma mepụta ribose phosphate.
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Haịrọdaịna (HAM)
Banyere Hydroaminase
E nwere ụdị ngwaahịa enzyme HAM abụọ (Nọmba dịka ES-HAM-101~ ES-HAM-102) nke SyncoZymes mepụtara. HAM nwere ike ime ka ammonia nke enoic acid ma ọ bụ ihe ndị sitere na ya pụta iji mepụta chiral amino acid. Enwere ike iji HAM mepụta chiral amino acid (ma ọ bụ chiral amines) site na enoic acid (ma ọ bụ alkenes). Onye na-enye Ammonia, dị ka mmiri ammonia ma ọ bụ nnu ammonium, dị mkpa.
Ụdị mmeghachi omume hydroaminase catalytic
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CALB anaghị arụ ọrụ
KALB
A na-emepụta Lipase B nke a na-akpọ Recombinant Lipase B nke sitere na Candida antarctica (CALB) site na ịgbaze mmiri n'ime mmiri na Pichia pastoris nke agbanwere mkpụrụ ndụ ihe nketa.
Enwere ike iji CALB mee ihe na mmiri ma ọ bụ organic phase catalytic esterification, esterolysis, transesterification, ring opening polyester synthesis, aminolysis, hydrolysis of amides, acylation of amines na mgbakwunye mmeghachi omume.
CALB nwere nnukwu nhọrọ chiral na nhọrọ ọnọdụ, yabụ enwere ike iji ya mee ihe n'ọtụtụ ebe na nhazi mmanụ, nri, ọgwụ, ịchọ mma na ụlọ ọrụ kemịkalụ ndị ọzọ.
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NADH oxidase (NOX)
Banyere NADH oxidase
ES-NOX (NADH oxidase): NOX na-eme ka oxidation nke NADH gaa na NAD+, ọ bụkwa nke oxidoreductase. N'ime usoro oxidation, O2 dị mkpa dị ka oxidant, ma belata ya ka ọ bụrụ H2O ma ọ bụ H2O2. E nwere ụdị ngwaahịa enzyme NOX anọ (ES-NOX-101~ES-NOX-104) nke ụlọ ọrụ anyị mepụtara, nke enwere ike iji mee ka oxidation dịghachi ndụ nke coenzyme NAD+.
Ụdị mmeghachi omume catalytic:
or
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Phenylalanine ammonia lyase (PAL)
Banyere Phenylalanine ammonia lyase
ES-PAL: Otu ụdị enzymes nke na-eme ka L-phenylalanine deamination ozugbo gaa na trans-cinnamic acid. Syncozymes mepụtara ihe iri nke phenylalanine ammonia lyase (nke nọmba ya bụ ES-PAL-101~ES-PAL-110), nke enwere ike iji mee ka phenylalanine deamination ma ọ bụ meghachi omume azụ nke phenylalanine na ihe ndị sitere na ya.
Ụdị mmeghachi omume catalytic:
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Catalase (CAT)
Banyere Catalase
ES-CAT (Catalase): na-eme ka H2O2 gbawaa ka ọ bụrụ oxygen na mmiri. Ọ dịkarịsịrị na mitochondria, endoplasmic reticulum, imeju anụmanụ na mkpụrụ ndụ ọbara uhie, ọkachasị na imeju na oke mkpokọta, na-enye ọrụ nchekwa antioxidant maka ahụ. Na biocatalysis, a na-ejikarị ya ewepụ mmeghachi omume site na ngwaahịa hydrogen peroxide ma belata mgbochi na mmechi nke enzyme site na hydrogen peroxide. Enwere naanị otu ụdị enzyme CAT nke SyncoZymes (Nọmba dị ka ES-CAT) mepụtara.
Ụdị mmeghachi omume catalytic:
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Lysine oxidase (LO)
Banyere Lysine oxidase
ES-LO (Lysine oxidase): na-eme ka L-lysine gbakee ka ọ bụrụ 6-amino-2-oxohexanoic acid (ma ọ bụ lactone ya). E nwere naanị otu ụdị enzyme LO (Nọmba dị ka ES-LO) nke SyncoZymes mepụtara.
Ụdị mmeghachi omume catalytic:
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Phosphokinase (PKase)
Banyere Phosphokinase
ES-PKase (Phosphokinase): na-akwalite mbufe nke otu phosphate na ATP gaa na ihe ndị ọzọ. Ọ na-akwalitekwa mbufe nke otu phosphate na nucleosides ndị ọzọ nke triphosphate mgbe ụfọdụ. Ọtụtụ kinases chọrọ ion metal divalent iji sonye na mmeghachi omume ahụ (n'ozuzu Mg2+). E nwere ụdị ngwaahịa enzyme PKase 21 (Nọmba dị ka ES-PKase101~ ES-PKase-121) nke SyncoZymes mepụtara.
Ụdị mmeghachi omume catalytic:
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Cyclooxygenase (COX)
Banyere Cyclooxygenase
ES-COX (Cyclooxygenase): na-akwalite mgbanwe nke njikọ C=C ka ọ bụrụ epoxide. E nwere ụdị ngwaahịa enzyme COX iri na otu (Nọmba dị ka ES-COX101~ ES-COX-111) nke SyncoZymes mepụtara. Dịka usoro catalytic dị iche iche si dị, a na-ekewa COX nke SyncoZymes n'ime haloperoxidase na styrene monooxygenase. ES-COX101, 102, 107-111 bụ nke haloperoxidase, ebe ES-COX103-106 bụ nke styrene monooxygenase.
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Cyclohexanone monooxygenase (CHMO)
Banyere Cyclohexanone monooxygenase
ES-CHMO (Cyclohexanone monooxygenase): Baeyer Villiger monooxygenase (BVMO) nwere cyclohexanone dị ka ihe ndabere, nwere ike ime ka cyclohexanone ghọọ cyclohexanol site na iji oxygen.
Ọ bụ ụdị enzyme dabere na flavin. A na-ebelata flavin nke e tinyere oxidized ka ọ bụrụ flavin site na usoro nke ibelata coenzyme II (NADPH) maka oxidation ọzọ. Ya mere, cofactor NADPH dị mkpa na usoro flavin. Enwere naanị otu ụdị ngwaahịa enzyme CHMO (Nọmba dị ka ES-CHMO101) nke SyncoZymes mepụtara, nke enwere ike iji mee ka cyclohexanone dịghachi ndụ ka ọ bụrụ cyclohexanone.
Ụdị mmeghachi omume catalytic:
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Carboxylic acid reductase (CAR)
Banyere Carboxylic acid reductase
ES-CAR (Carboxylic acid reductase): na-akwalite mbelata nke otu carboxyl gaa na otu aldehyde. N'ime usoro catalytic, a chọrọ ka ATP rụọ ọrụ na coenzyme NADPH dị ka ndị na-ebuga hydrogen. E nwere ụdị ngwaahịa enzyme CAR abụọ (Nọmba dị ka ES-CAR101~ ES-CAR-102) nke SyncoZymes mepụtara.
Ụdị mmeghachi omume catalytic:
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Phenylalanine dehydrogenase (PDH)
Banyere Phenylalanine dehydrogenase
ES-PDH: Otu ụdị oxidoreductase. Mmeghachi omume dị mma nwere ike ime ka nnu L phenylalanine ghara ịdị ọcha n'ihu NAD iji mepụta nnu phenylpyruvate, mmeghachi omume azụ ahụ nwekwara ike ime ka mmepụta nke nnu amino acid kwekọrọ na ya site na nnu phenylpyruvate. Syncozymes mepụtara ihe 8 nke phenylalanine dehydrogenase (nke nọmba ya bụ ES-PDH-101~ES-PDH-108). Enwere ike iji ES-PDH kwadebe nnu phenylalanine ma ọ bụ nnu amino acid kwekọrọ na ya site na nnu phenylpyruvic acid ma ọ bụ ihe ndị sitere na ya.
Ụdị mmeghachi omume catalytic:
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Ozi-e:lchen@syncozymes.com
