Amine Dehydrogenase (AmDH)
Nkọwa Dị Mkpirikpi:
Banyere Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzyme nke nwere ike ime ka otu carbonyl dị n'otu ammonia ma belata ya ka ọ bụrụ otu amino. Ọ bụ enzyme dabere na coenzyme NADH, NADH na-arụkwa ọrụ dị ka onye na-ebufe hydrogen. E nwere ụdị ngwaahịa enzyme AmDH anọ (Nọmba dị ka ES-AmDH101～ES-AmDH104) nke SyncoZymes mepụtara, nke enwere ike iji na regioselective ma ọ bụ stereoselective reductive amino nke aldehydes na ketones.
Ụdị mmeghachi omume catalytic:
Mkpanaka/Wechat/WhatsApp: +86-13681683526
Ozi-e:lchen@syncozymes.com
★ Nkọwapụta ihe dị elu nke substrate.
★ Ịhọrọ chiral siri ike.
★ Mgbanwe dị elu.
★ Ngwaahịa ndị na-adịghị mma.
★ Ọnọdụ mmeghachi omume dị nro.
★ Ọ dị mma maka gburugburu ebe obibi.
➢ Dịka ọ na-adịkarị, usoro mmeghachi omume kwesịrị ịgụnye ihe ndị dị n'ime ya, ihe ngwọta nchekwa, enzyme, coenzyme na sistemụ mmeghari coenzyme (dịka ọmụmaatụ glucose na glucose dehydrogenase).
➢ A ga-etinye AmDH ikpeazụ n'ime sistemụ mmeghachi omume, mgbe pH na okpomọkụ gbanwere na ọnọdụ mmeghachi omume.
Ihe atụ nke 1 (Njikọ nke chiral amines kwekọrọ na ya site na mweghachi nke alkyl aryl ketones)(1):
Debe ya n'ime ebe dị jụụ ruo afọ 2 n'okpuru -20 ℃.
Emetụla aka na ọnọdụ dị oke njọ dịka: oke okpomọkụ, oke pH dị elu/ala na oke ihe mgbaze organic.
1. Kong W, Liu Y, Huang C, et al. Angewandte Chemie International Edition, 2022: e202202264.
