Cytochrome P450 monooxygenase (CYP)

Nkọwa Dị Mkpirikpi:

Banyere CYP

ES-CYPs: Otu ụdị enzymes redox nwere mercaptan-heme dị ka ebe etiti na-arụ ọrụ iji mee ka nnyefe oxygen dị ike. Ha bụ oxygenases njedebe ma chọọ heme iji mee ka oxygen rụọ ọrụ.

Cytochrome P450 monooxygenase na-akwalite oxidation, epoxidation na hydroxylation nke alkyl, hydroxylation na oxidation nke ammonia, oxidation nke sọlfọ, dealkylation (oxygen, sọlfọ, ammonia), oxidative dehydrogenation, deamination na dehalogenation.
E nwere ụdị ngwaahịa cytochrome P450 monooxygenase asatọ (nọmba dị ka ES-CYP-101～ES-CYP-108) nke SyncoZymes mepụtara.

Mkpanaka/Wechat/WhatsApp: +86-13681683526

Ozi-e:lchen@syncozymes.com

Zitere anyị ozi-e

Nkọwa Ngwaahịa

Akara Ngwaahịa

Banyere CYP:

Ụdị mmeghachi omume catalytic:

Ozi Ngwaahịa:

Enzymes	Ngwa Nlele (SynKit)	Nkọwapụta
Ntụ ntụ Enzyme	ES-CYP-101~ ES-CYP-108	otu setịpụ nke Cytochrome P450 Monooxygenases asatọ, 50 mg nke ọ bụla 8 * 50mg / ihe, ma ọ bụ ọnụọgụ ndị ọzọ
Ngwa Nlele (SynKit)	ES-CYP-800	otu setịpụ nke Cytochrome P450 Monooxygenases asatọ, 1mg nke ọ bụla 8 * 1mg / ihe

Uru:

★ Ọdịdị sara mbara nke substrate.
★ Mgbanwe dị elu.
★ Ngwaahịa ndị na-adịghị mma.
★ Ọnọdụ mmeghachi omume dị nro.
★ Ọ dị mma maka gburugburu ebe obibi.

Ntuziaka maka ojiji:

➢ Dịka ọ na-adịkarị, sistemụ mmeghachi omume kwesịrị ịgụnye ihe ndị dị n'ime ya, ihe ngwọta nchekwa (PH mmeghachi omume kachasị mma nke enzyme), coenzyme (NAD(H) ma ọ bụ NADP(H)), sistemụ mmeghachi omume coenzyme (dịka ọmụmaatụ glucose na glucose dehydrogenase) na sistemụ mmeghachi omume nke ES-CYP nwere ike iji hydrogen peroxide dochie sistemụ mmeghachi omume nke akụkụ.
➢ A ga-amụ ụdị ES-CYP niile dabara na ọnọdụ mmeghachi omume kachasị mma dị iche iche n'otu n'otu.
➢ Nnukwu ihe e ji etinye ihe n'ime ala ma ọ bụ ngwaahịa nwere ike igbochi ọrụ ES-CYP. Agbanyeghị, enwere ike ibelata mgbochi ahụ site na itinye ihe e ji etinye ihe n'ime ala n'otu oge.

Ihe Nlereanya Ngwa:

Ihe atụ nke 1⁽¹⁾:

Ihe atụ nke abụọ⁽²⁾:

Ihe atụ nke atọ⁽³⁾:

Ihe atụ nke anọ⁽⁴⁾:

Nchekwa:

Debe ya n'ime ebe dị jụụ ruo afọ 2 n'okpuru -20 ℃.

Nlebara anya:

Emetụla aka na ọnọdụ dị oke njọ dịka: oke okpomọkụ, oke pH dị elu/ala na oke ihe mgbaze organic.

Ntụaka:

1. Zaretzki J, Matlock M, na Swamidass S JJ Chem. Inf. Model, 2013, 53, 3373–3383.
2. Gannett P M., Kabulski J, Perez F A., na Tal. J. Am. Chem. Soc., 2006, 128 (26), 8374–8375.
3. Cryle M J., Matovic N J., na De Voss J J. Org. Lett., 2003, 5 (18), 3341–3344.
4. Kawauchi, H., Sasaki, J., Adachi, T., e tal. Biochim. Biophys. Acta, 1994, 1219, 179.
5. Yasutake, Y., Fujii, Y.; Cheon, WK na Tal. Acta Crystallogr. 2009, 65, 372.