Imine reductase (IRED)
Nkọwa Dị Mkpirikpi:
Banyere Imine reductase
ES-IRED: Otu ụdị enzymes nke na-akwalite mbelata njikọ C=N na njikọ CN. Ọ bụ nke redox enzyme, yana coenzyme NADPH maka njem hydrogen. Dịka mmasị chiral nke ngwaahịa ndị a si dị, enwere ike kewaa ha n'ime R-IRED na S-IRED. Syncozymes mepụtara 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), nke enwere ike iji nke ukwuu na mbelata regioselective na stereoselective nke imines iji kwadebe chiral amines.
Ụdị mmeghachi omume catalytic:
Mkpanaka/Wechat/WhatsApp: +86-13681683526
Ozi-e:lchen@syncozymes.com
| Enzymes | Koodu Ngwaahịa | Nkọwapụta |
| Ntụ ntụ Enzyme | ES-IRED-101~ ES-IRED-114 | otu 14 Imine Reductase, 50 mg nke ọ bụla |
| Ngwa Nnyocha Enzyme 96-Well | ES-IRED-1400 | otu 14 Imine Reductase, 1 mg nke ọ bụla |
★ Nkọwapụta ihe dị elu nke substrate.
★ Ịhọrọ chiral siri ike.
★ Mgbanwe dị elu.
★ Ngwaahịa ndị na-adịghị mma.
★ Ọnọdụ mmeghachi omume dị nro.
★ Ọ dị mma maka gburugburu ebe obibi.
➢ Dịka ọ na-adịkarị, usoro mmeghachi omume kwesịrị ịgụnye ihe ndị dị n'ime ya, ihe ngwọta nchekwa, enzyme, coenzyme, na sistemụ mmeghari coenzyme.
➢ A ga-amụ ụdị ES-IRED niile dabara na ọnọdụ mmeghachi omume kachasị mma dị iche iche n'otu n'otu.
➢ Nnukwu ihe e ji etinye ihe n'ime ala ma ọ bụ ngwaahịa nwere ike igbochi ọrụ ES-IRED. Agbanyeghị, enwere ike ibelata mgbochi ahụ site na itinye ihe e ji etinye ihe n'ime ala n'otu oge.
Ihe atụ nke 1(Biosynthesis nke chiral 2-methyl pyrrolidine)(1):
Ihe atụ nke abụọ (Biosynthesis nke amine nke abụọ)(2):
Ihe atụ nke 3 (Mbelata nke ihe ndị na-agbanwe agbanwe)(3):
Debe ya n'ime ebe dị jụụ ruo afọ 2 n'okpuru -20 ℃.
Emetụla aka na ọnọdụ dị oke njọ dịka: oke okpomọkụ, oke pH dị elu/ala na oke ihe mgbaze organic.
1. Scheller PN, Fademrecht S, Hofelzer S, et al. ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, na ndị ọzọ. ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al. Adv. Synth. Catal. 2015, 357, 1692-1696.
